Serum Thyroglobulin and Thyroglobulin Autoantibodies in Thyroid Diseases
نویسندگان
چکیده
منابع مشابه
Serum thyroglobulin and thyroid cancer.
Thyroglobulin is a large glycosylated protein (MW 660000 daltons) which is synthesised and secreted by the thyroid cell into the follicular lumen. In the thyroglobulin molecule the iodotyrosines undergo oxidative coupling to form the iodothyronines thyroxine (T4) and triiodothyronine (T3). Production of thyroid hormones results from micropinocytosis of iodinated thyroglobulin from the colloid i...
متن کاملSerum thyroglobulin autoantibodies: prevalence, influence on serum thyroglobulin measurement, and prognostic significance in patients with differentiated thyroid carcinoma.
The prevalence of circulating thyroid autoantibodies (TgAb or antithyroid peroxidase) was increased nearly 3-fold in patients with differentiated thyroid cancers (DTC) compared with the general population (40% vs. 14%, respectively). Serum TgAb (with or without antithyroid peroxidase) was present in 25% of DTC patients and 10% of the general population. Serial postsurgical serum TgAb and serum ...
متن کاملIdentification of thyroid hormone residues on serum thyroglobulin: a clue to the source of circulating thyroglobulin in thyroid diseases.
Thyroglobulin (Tg) present in the serum of normal individuals and patients with thyroid disorders could be partly newly synthesized non-iodinated Tg and partly Tg containing iodine and hormone residues originating from the lumen of thyroid follicles. With the aim of examining the contribution of the latter source of Tg to the elevation of serum Tg concentration in thyroid pathophysiological sit...
متن کاملThyroid Hormone Synthesis in Thyroglobulin
~-14C]Tyrosine-labeled noniodinated hog thyroglobulin was iodinated enzymatically and nonenzymatically (iodine, iodide-chloramine-T, pH 7.4, or iodine monochloride, p.H 8.1). This led to similar levels of iodine incorporatzon as well as of thyroid hormone synthesis. Iodine monochloride at pH 5.5 formed “hormonogenic” iodotyrosine residues, but no hormone residues. The latter were formed when th...
متن کاملThe value of thyroglobulin measurement in different thyroid disorders [Persian]
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ژورنال
عنوان ژورنال: Allergy
سال: 1983
ISSN: 0105-4538
DOI: 10.1111/j.1398-9995.1983.tb05081.x